NEW PERSPECTIVES OF GENE THERAPY ON POLYGLUTAMINE SPINOCEREBELLAR ATAXIAS: FROM MOLECULAR TARGETS TO NOVEL NANOVECTORS

New Perspectives of Gene Therapy on Polyglutamine Spinocerebellar Ataxias: From Molecular Targets to Novel Nanovectors

Seven of the most frequent spinocerebellar ataxias (SCAs) are lite brite caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes, which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intracellular in

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Self-rated sleep quality and mood states of Brazilian fighters

Sleep has a direct relationship with mood.In this context, the aim of this study was to analyze the relationship between sleep quality and mood of combat sport athletes.A total of 188 elite male combat sports athletes participated in the study.Athletes who reported good sleep have Nutritionals - Thickeners greater vigor during competition than athl

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Experimental and Nonlinear Finite Element Analysis Data for an Innovative Buckling Restrained Bracing System to Rehabilitate Seismically Deficient Structures

This article presents experimental data and nonlinear finite element analysis (NLFEA) modeling for an innovative buckling restrained bracing (BRB) system.The data were collected from qualification testing of introduced BRBs per the AISC 341 test provision and finite element modeling.The BRB is made of three parts: core bar, restraining unit, and en

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